Pharmacoeconomics of Helicobacter pylori: eradication versus maintenance therapy in controlling peptic ulcer disease.
نویسندگان
چکیده
We performed an electronic search in Medline and EMBASE for papers comparing Helicobacter pylori eradication and H(2)RA-maintenance therapy in peptic ulcer. Treatment to eradicate H. pylori in patients with a proven ulcer has a favorable cost-effectiveness compared with maintenance therapy, with benefits for the patient and society. In most studies, it was assumed that no more gastrointestinal drugs were needed after eradication. Additional research is needed to provide empirical evidence on gastrointestinal drug utilization after eradication of H. pylori. The development of a vaccine against H. pylori remains however the ultimate goal in the fight against peptic ulcer disease.
منابع مشابه
The need for Helicobacter pylori eradication therapy in patients with peptic ulcer bleeding.
Peptic ulcer bleeding is an important complication of peptic ulceration. The condition carries significant morbidity and mortality despite advances in both endoscopic intervention techniques and pharmacological treatment. About one third of patients have a recurrence of bleeding within a few years of discharge. Before Helicobacter pylori was discovered, most of these patients were given mainten...
متن کاملEradication therapy for peptic ulcer disease in Helicobacter pylori positive patients.
BACKGROUND Peptic ulcer disease is the cause for dyspepsia in about 10% of patients. 95% of duodenal and 70% of gastric ulcers are associated with Helicobacter pylori. Eradication of H pylori reduces the relapse rate of ulcers but the magnitude of this effect is uncertain. OBJECTIVES The primary outcomes were the proportion of peptic ulcers healed initially and proportion of patients free fro...
متن کاملH. pylori eradication therapy vs. antisecretory non-eradication therapy (with or without long-term maintenance antisecretory therapy) for the prevention of recurrent bleeding from peptic ulcer.
BACKGROUND Peptic ulcer is the main cause for upper gastrointestinal haemorrhage, and Helicobacter pylori infection is the main etiologic factor for peptic ulcer disease. Maintenance antisecretory therapy has been the standard long-term treatment for patients with bleeding ulcers to prevent recurrent bleeding. On the other hand, the precise efficacy of H. pylori eradication for the prevention o...
متن کامل[Drug therapy of peptic ulcer disease].
Healing of peptic ulcers can be achieved by using a variety of anti-ulcer medications. The most commonly used agents include the histamine-2 receptor antagonists (H2RAs) and the proton pump inhibitors. They are also efficacious in preventing ulcer recurrence providing maintenance treatment is given. The ideal treatment for peptic ulcers today is aiming at eradication of Helicobacter pylori infe...
متن کاملEradication of Helicobacter pylori for the prevention of peptic ulcer rebleeding.
AIM To evaluate the effect of Helicobacter pylori eradication on ulcer bleeding recurrence in a prospective, long-term study including more than 400 patients. METHODS Patients with peptic ulcer bleeding were prospectively included. H. pylori infection was confirmed by rapid urease test, histology or (13)C-urea breath test. Several eradication regimens were used. Ranitidine 150 mg was administ...
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عنوان ژورنال:
- Expert review of pharmacoeconomics & outcomes research
دوره 1 1 شماره
صفحات -
تاریخ انتشار 2001